Endocrine Abstracts

Hormone-responsive reporter plasmids are widely used for the analysis of endocrine responses in target cells. We have investigated the effect of different promoters on reporter gene expression by oestrogen-responsive reporter constructs.Plasmid constructs were transfected into an oestrogen responsive bovine endometrial stromal (BST) cell line. Two reporter gene products were analysed: secreted alkaline phosphatase(SeAP) and beta galactosidase.<p clas...

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The selenoenzyme plasma glutathione peroxidase (GPx3, pGPx) is highly expressed in thyroid, kidney, placenta and bronchio-epithelial tissue. In the thyroid gland, the enzyme is thought to regulate thyroid hormone production by controlling the availability of H2O2, the cosubstrate for thyroperoxidase (TPO) and to protect the thyrocyte against H2O2-induced oxidative damage. To explain the high thyroidal expression levels, we studied GP...